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KMID : 0931320150150030182
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대한상부위장관.헬리코박터학회지
2015 Volume.15 No. 3 p.182 ~ p.186
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A Collision Tumor Comprising Early Gastric Adenocarcinoma and Diffuse Large B-cell Lymphoma after Endoscopic Gastric Submucosal Dissection
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김상선:Kim Sang-Sun
김병관:Kim Byeong-Gwan/조아영:Cho A-Young/이성희:Lee Seong-Hee/신홍식:Shin Hong-Shik/윤소희:Yun So-Hee/조진웅:Cho Jin-Woong/주명진:Joo Myung-Jin
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Abstract
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Concurrence of primary gastric adenocarcinoma and lymphoma have been described very rarely in the literature; its incidence is estimated at 0.08%. To our knowledge, there are no reports about a collision tumor comprising early gastric cancer and diffuse large B-cell lymphoma from the same lesion. The term “collision tumor” refers to the coexistence of two or more histologically distinct tumors within the same mass with no histologic admixture. A 76-year-old man complained of a 5-month-history of dyspepsia, and underwent esophagogastroduodenoscopy. Endoscopic findings showed a nodular, round, flat mass lesion in the upper body, therefore we performed endoscopic submucosal dissection (ESD). Pathologic findings revealed a well-differentiated adenocarcinoma accompanied by diffuse large B-cell lymphoma without evidence of Helicobacter pylori infection. Conventional CT and PET-CT scans revealed metastatic lymph nodes in the parotid gland, submandibular gland, maxillary gland and the inguinal regions. The pathogenesis of a collision tumor comprising two different cancers is not well understood. In addition, there are no established treatment guidelines in this series. In the current case, the patient underwent ESD for the removal of adenocarcinoma concomitantly with chemotherapy for the management of metastatic lymphoma.
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KEYWORD
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Gastric adenocarcinoma, Lymphoma, large B-Cell, diffuse, Collision, Stomach neoplasms
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